A team of researchers from The Scripps Research Institute (TSRI) and the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen) has developed a vaccine that provides immunity against a broad range of influenza subtypes. While yearly flu shots provide protection, influenza virus mutates rapidly, and these vaccines are incapable to provide immunity against the subtypes. To create a ‘universal’ vaccine that could safeguard an organism from a broad array of viruses, the researchers focused on hemagglutinin (HA), a protein that is present on the surface of all subtypes of influenza. While conventional vaccines target the ‘head’ of HA, this team targeted its long “stem” region which is similar across different flu strains and seldom mutates. To design the vaccine, they looked to influenza’s own structure, specifically the universal recognition site of the broadly protective antibody CR9114 in the HA stem. They used the vaccine on rodents and non-human primates and found that they produced antibodies that could truss with HAs in many influenza subtypes and even neutralize H5N1 viruses. “While there is more work to be done, the ultimate aim, of course, would be to create a life-long vaccine,” said Ian Wilson, Hansen Professor of Structural Biology and chair of the Department of Integrative Structural and Computational Biology at TSRI.

Read more in Science Daily. 

Related video: What the Internet is Doing to Our Brains


admin_en | 1@1.com

Related Posts

Martha Stewart Weddings, Spring 1999 Almost every aspect of planning a wedding throws up one choice after another, so it may come as a ease to recognize that there is one custom-made no one has to debate: Every bounty must be acknowledged with a individual, handwritten thank-you note. Preprinted or typed notes won’t do. And […]

The face of research and publication is switching globally. Due to the intense competition in academia, there is immense pressure on scientists to publish at a quick tempo. On the contrary, the journal publication process is slow and researchers scramble to establish scientific priority on their work to avoid getting scooped. The role of researchers […]

7 Rules for Writing To my astonishment (and delight), Malcolm Gladwell has selected Drive as the March pick for the Fresh Yorker Online Book Club. And as a way to gear up readers for the discussion, the magazine asked me a few questions — including whether I had any «rules» for writing. I’d actually never […]

Leave a Reply

Your email address will not be published. Required fields are marked *